Tag: liver
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Two Manifestations of Oxidative Stress: Cataracts and Steatotic Liver Disease
The following two examples — one on age-related cataracts, and one on Steatotic Liver Disease (SLD) — both illustrate how cells try to compensate for oxidative stress, and what happens when those compensatory systems eventually fail. Oxidative Stress and Cataract Formation Huang et al. (2022) investigated how biliverdin reductase A protects lens epithelial cells from…
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What Happens in the Body When Alcohol Dehydrogenase Goes to Work
I’ve been digging into a few studies on alcohol dehydrogenase — the enzyme responsible for the first step of ethanol metabolism, oxidizing ethanol to acetaldehyde while reducing NAD+ to NADH. I found some genuinely strange toxicology, and some insight into hangovers. When It’s Not Ethanol: A Forensic Toxicology Case Ethanol is not the only substrate…
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St, John’s Wort and CYP450 Pathways
Dürr et al. (2000) gave 300 mg of St. John’s Wort to healthy volunteers three times a day for two weeks. They found that this induced CYP3A4 in both the liver and the intestines, which explained the interactions that had been observed between St. John’s wort and certain drugs. It seems that it reduced the…
