Northern Nutritionals

Tag: CYP450

  • What Happens in the Body When Alcohol Dehydrogenase Goes to Work

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    by

    Karline Jensen
    in

    I’ve been digging into a few studies on alcohol dehydrogenase — the enzyme responsible for the first step of ethanol metabolism, oxidizing ethanol to acetaldehyde while reducing NAD+ to NADH. I found some genuinely strange toxicology, and some insight into hangovers. When It’s Not Ethanol: A Forensic Toxicology Case Ethanol is not the only substrate…

  • St, John’s Wort and CYP450 Pathways

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    by

    Karline Jensen
    in

    Dürr et al. (2000) gave 300 mg of St. John’s Wort to healthy volunteers three times a day for two weeks.  They found that this induced CYP3A4 in both the liver and the intestines, which explained the interactions that had been observed between St. John’s wort and certain drugs.  It seems that it reduced the…